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Allele : Cers3<tm1.1Rsnd> ceramide synthase 3; targeted mutation 1.1, Roger Sandhoff
Primary Identifier  MGI:5307225 Allele Type  Targeted
Attribute String  Null/knockout Gene  Cers3
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
molecularNote  An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 7. An additional loxP site was inserted downstream of exon 7. Cre-mediated recombination remvoed exon 7. RT-PCR confirmed the expression of a truncated transcript. Immunohistochemistry confirmed the absence of protein expression in the stratum spinosum and stratum granulosum.
  • mutations:
  • Intragenic deletion,
  • Insertion
  • synonyms:
  • CerS3<d>,
  • CerS3<d>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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5 Publication categories

Trail: Allele




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