| First Author | Jones PH | Year | 2013 |
| Journal | Virology | Volume | 444 |
| Issue | 1-2 | Pages | 124-39 |
| PubMed ID | 23806386 | Mgi Jnum | J:314599 |
| Mgi Id | MGI:6822541 | Doi | 10.1016/j.virol.2013.05.042 |
| Citation | Jones PH, et al. (2013) BST-2/tetherin is overexpressed in mammary gland and tumor tissues in MMTV-induced mammary cancer. Virology 444(1-2):124-39 |
| abstractText | BST-2 restricts MMTV replication, but once infection has established, MMTV modulates BST-2 levels. MMTV-directed BST-2 modulation is tissue-specific and dependent on infection and neoplastic transformation status of cells. In the lymphoid compartment of infected mice, BST-2 expression is first upregulated and then significantly downregulated regardless of absence or presence of mammary tumors. However, in mammary gland tissues, upregulation of BST-2 expression is dependent on the presence of mammary tumors and tumor tissues themselves have high BST-2 levels. Elevated BST-2 expression in these tissues is not attributable to IFN since levels of IFNalpha and IFNgamma negatively correlate with BST-2. Importantly, soluble factors released by tumor cells suppress IFNalpha and IFNgamma but induce BST-2. These data suggest that overexpression of BST-2 in carcinoma tissues could not be attributed to IFNs but to a yet to be determined factor that upregulates BST-2 once oncogenesis is initiated. |
