Primary Identifier | MGI:5312653 | Allele Type | Spontaneous |
Attribute String | Null/knockout | Gene | Mfrp |
Inheritance Mode | Recessive | Strain of Origin | 129S-Per3<tm1Drw>/J |
Is Recombinase | false | Is Wild Type | false |
description | This mutation was originally identified in mice carrying Per3tm1Drw on a 129 background. |
molecularNote | A spontaneous mutation resulted in the the deletion of a single G nucleotide from the GGGGG sequence in exon 3. This mutation causes a frame shift and premature stop codon in the first third of the 14 predicted exons. Western blot analysis confirmed the absence of protein expression in whole eyecups. |