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Allele : Tg(CAG-EGFP,TGFB1*)C8Kul transgene insertion C8, Ashok B Kulkarni
Primary Identifier  MGI:5319386 Allele Type  Transgenic
Attribute String  Conditional ready, Constitutively active, Inserted expressed sequence, Reporter Gene  Tg(CAG-EGFP,TGFB1*)C8Kul
Strain of Origin  FVB/NCrl Is Recombinase  false
Is Wild Type  false
molecularNote  The transgene was designed with (from 5' to 3') the CAG promoter (containing a CMV-IE enhancer/beta-actin promoter), a loxP-flanked enhanced green fluorescent protein (EGFP) and polyA signal, a hemagglutinin (HA)-tagged porcine transforming growth factor, beta 1 (Tgfb1) cDNA, and a 2x-polyA signal. The Tgfb1 cDNA was modified to be constitutively active by missense mutations of two cysteine residues (C223 and C225) to serines. Line C8 was generated.
  • mutations:
  • Insertion
  • synonyms:
  • Tg(CAG-EGFP,TGFB1*)C8Akul,
  • beta1<glo>,
  • beta1<glo>,
  • Tg(CAG-EGFP,TGFB1*)C8Akul
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

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0 Driven By

6 Publication categories

Trail: Allele




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