| First Author | Rademakers R | Year | 2021 |
| Journal | Brain Pathol | Volume | 31 |
| Issue | 3 | Pages | e12945 |
| PubMed ID | 33709463 | Mgi Jnum | J:357460 |
| Mgi Id | MGI:7763978 | Doi | 10.1111/bpa.12945 |
| Citation | Rademakers R, et al. (2021) Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits. Brain Pathol 31(3):e12945 |
| abstractText | TMEM106B has been recently implicated in multiple neurodegenerative diseases. Here, Rademakers et al. report a late-onset cerebellar Purkinje cell loss and progressive decline in motor function and gait deficits in a conventional Tmem106b-/- mouse model. By using high-power microscopy and bulk RNA sequencing, the authors further identify lysosomal and immune dysfunction as potential underlying mechanisms of the Purkinje cell loss. |
