Primary Identifier | MGI:5423977 | Allele Type | Spontaneous |
Attribute String | Modified isoform(s) | Gene | S1pr2 |
Strain of Origin | C57BL/6Brd-Tyr<c-Brd> | Is Recombinase | false |
Is Wild Type | false |
molecularNote | The molecular lesion is a C-to-G transition in codon 289, resulting in a threonine to arginine change (p.T289R) in a highly conserved region of the encoded protein. The encoded protein is expressed at similar levels and a similar spatiotemporal manner in controls and in homozygous mice, as assayed by immunohistochemistry. |