First Author | Sutrave P | Year | 1990 |
Journal | Genes Dev | Volume | 4 |
Issue | 9 | Pages | 1462-72 |
PubMed ID | 2253874 | Mgi Jnum | J:184590 |
Mgi Id | MGI:5424885 | Doi | 10.1101/gad.4.9.1462 |
Citation | Sutrave P, et al. (1990) ski can cause selective growth of skeletal muscle in transgenic mice. Genes Dev 4(9):1462-72 |
abstractText | We have created several lines of mice that contain a truncated chicken c-ski cDNA linked to an MSV LTR promoter. Adult mice from three independent lines show large increases in skeletal muscle. All three lines of mice express high levels of c-ski mRNA and protein in skeletal muscle. All other tissues examined show little or no expression of the c-ski transgene. The muscles of one of the three lines were examined in more detail. Type II fast fibers undergo selective hypertrophy in affected muscles of this line. |