Primary Identifier | MGI:5320901 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Gnas |
Transmission | Germline | Strain of Origin | 129S4/SvJae |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Cre-meditated recombination inverted the exon 2SA and lacZ leaving a lox2272 site at the 5' end and loxP site at the 3' end. The allele expresses a fusion product between the XL domain and lacZ. qRT-PCR confirmed a 90% downregulation of transcript expression. |