Primary Identifier | MGI:5427817 | Allele Type | Targeted |
Attribute String | Inserted expressed sequence, Reporter | Gene | Drd1 |
Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A Venus reporter fused to human IL2RA with a polydaenylation sequence and a floxed neo cassette was inserted upstream of exon 2. Cre-mediated recombination removed the neo cassette. Treatment with a recombinant immunotoxin (variable anti-IL2RA regions fused to a bacterial exotoxin fragment) results in ablation of cells expressing this allele. |