| First Author | Forzati F | Year | 2014 |
| Journal | Biol Open | Volume | 3 |
| Issue | 9 | Pages | 871-9 |
| PubMed ID | 25190058 | Mgi Jnum | J:213773 |
| Mgi Id | MGI:5586585 | Doi | 10.1242/bio.20147872 |
| Citation | Forzati F, et al. (2014) CBX7 gene expression plays a negative role in adipocyte cell growth and differentiation. Biol Open 3(9):871-9 |
| abstractText | We have recently generated knockout mice for the Cbx7 gene, coding for a polycomb group protein that is downregulated in human malignant neoplasias. These mice develop liver and lung adenomas and carcinomas, which confirms a tumour suppressor role for CBX7. The CBX7 ability to downregulate CCNE1 expression likely accounts for the phenotype of the Cbx7-null mice. Unexpectedly, Cbx7-knockout mice had a higher fat tissue mass than wild-type, suggesting a role of CBX7 in adipogenesis. Consistently, we demonstrate that Cbx7-null mouse embryonic fibroblasts go towards adipocyte differentiation more efficiently than their wild-type counterparts, and this effect is Cbx7 dose-dependent. Similar results were obtained when Cbx7-null embryonic stem cells were induced to differentiate into adipocytes. Conversely, mouse embryonic fibroblasts and human adipose-derived stem cells overexpressing CBX7 show an opposite behaviour. These findings support a negative role of CBX7 in the control of adipocyte cell growth and differentiation. |
