| First Author | Wilharm A | Year | 2019 |
| Journal | Eur J Immunol | Volume | 49 |
| Issue | 5 | Pages | 686-693 |
| PubMed ID | 30758858 | Mgi Jnum | J:277784 |
| Mgi Id | MGI:6317075 | Doi | 10.1002/eji.201848033 |
| Citation | Wilharm A, et al. (2019) Styk1 is specifically expressed in NK1.1(+) lymphocytes including NK, gammadelta T, and iNKT cells in mice, but is dispensable for their ontogeny and function. Eur J Immunol 49(5):686-693 |
| abstractText | Innate T cells, NK cells, and innate-like lymphocytes (ILCs) share transcriptional signatures that translate into overlapping developmental and functional programs. A prominent example for genes that are highly expressed in NK cells but not in ILCs is serine-threonine-tyrosine kinase 1 (Styk1 encoded by Styk1). We found Styk1 to be specifically expressed in lymphocytes positive for Killer cell lectin-like receptor subfamily B, member 1, also known as CD161 or NK1.1, i.e. in NK cell, alphabeta iNKT, and gammadelta NKT cell lineages. To investigate the role of Styk1 in the development and function of NK1.1(+) innate T-cell subsets, we generated and analyzed a novel Styk1(null) mutant mouse line. Furthermore, we validated Styk1 expression in gammadelta NKT cells and in thymic, but not in peripheral invariant alphabeta iNKT cells through ex vivo analysis of a concomitantly generated transgenic Styk1 reporter mouse line. Despite the very specific expression of Styk1 in NK cells, gammadelta NKT cells, and thymic alphabeta iNKT, its absence did not alter homeostasis and function of these lineages. Thus, Styk1 expression is specific for NK cells and selected NK-like innate T-cell subsets, but dispensable for their development and function. |
