| First Author | Yamakado H | Year | 2012 |
| Journal | Neurosci Res | Volume | 73 |
| Issue | 2 | Pages | 173-7 |
| PubMed ID | 22475625 | Mgi Jnum | J:185434 |
| Mgi Id | MGI:5428785 | Doi | 10.1016/j.neures.2012.03.010 |
| Citation | Yamakado H, et al. (2012) alpha-Synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior and hyperlocomotion. Neurosci Res 73(2):173-7 |
| abstractText | alpha-Synuclein (alpha-syn), the main component of Lewy bodies, was identified as a genetic risk factor for idiopathic Parkinson's disease (PD). As a model for PD, we generated human alpha-syn bacterial artificial chromosome transgenic mice (BAC tg mice) harboring the entire human alpha-syn gene and its gene expression regulatory regions. The alpha-syn BAC tg mice manifested decreased anxiety-like behaviors which may reflect non-motor symptoms of early PD, and they exhibited increased SERT expression that may be responsible for decreased anxiety-like behaviors. Our alpha-syn BAC tg mice could be a valuable tool to evaluate alpha-syn gene dosage effects in vivo. |
