| Primary Identifier | MGI:5432032 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(CAG-Cfh*)#Mcp |
| Strain of Origin | (CBA x C57BL/6)F1 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | A modified version of the CAGGS promoter drives expression of a mouse Cfh gene with a Cys937Stop mutation resulting in a truncated protein that lacks the terminal five SCR domains. The truncated protein is detected in the plasma at levels comparable to the wild-type protein. The truncated protein retained complement regulatory activity but showed impaired binding to heparin and human umbilical vein endothelial cells in vitro. |
