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Allele : Tg(Wnt1-flpe/ERT2)9455Dym transgene insertion 9455, Susan Dymecki
Primary Identifier  MGI:5432117 Allele Type  Transgenic
Attribute String  Inducible, Recombinase Gene  Tg(Wnt1-flpe/ERT2)9455Dym
Strain of Origin  (C57BL/6 x SJL)F2 or FVB Induced With  tamoxifen
Is Recombinase  true Is Wild Type  false
molecularNote  The construct was constructed by inserting a cassette containing the flpe/ERT2 coding and polyA sequences into a Wnt1 expression-vector. 11 kb of Wnt1 genomic DNA containing critical 3' enhancer sequences were included after the FLPe/ERT2 cassette. Tandem insulator sequences flanked the complete construct. The purified transgene was injected into fertilized eggs to produce transgenic animals. 11 lines were obtained and FLPe/ERT2 mRNA expression recapitulated endogenous Wnt1 expression. Two lines showing the highest levels of FLPe/ERT2 mRNA were characterized with respect to recombinase activity. Data from line 9455 was shown in detail.
  • mutations:
  • Insertion
  • synonyms:
  • Wnt1::FlpeER<T2>,
  • Wnt1::FlpeER<T2>
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Trail: Allele

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