| First Author | Lassen LB | Year | 2018 |
| Journal | PLoS One | Volume | 13 |
| Issue | 4 | Pages | e0196056 |
| PubMed ID | 29698510 | Mgi Jnum | J:262057 |
| Mgi Id | MGI:6156233 | Doi | 10.1371/journal.pone.0196056 |
| Citation | Lassen LB, et al. (2018) ELISA method to detect alpha-synuclein oligomers in cell and animal models. PLoS One 13(4):e0196056 |
| abstractText | Soluble aggregates of alpha-synuclein, so-called oligomers, are hypothesized to act as neurotoxic species in Parkinson's disease, Lewy body dementia and multiple systems atrophy, but specific tools to detect these aggregated species are only slowly appearing. We have developed an alpha-synuclein oligomer ELISA that allows us to detect and compare alpha-synuclein oligomer levels in different in vivo and in vitro experiments. The ELISA is based on commercially available antibodies and the epitope of the capture antibody MJF14-6-4-2 is folding- and aggregate-dependent and not present on monomers. |
