| First Author | Zhang W | Year | 2020 |
| Journal | J Cell Mol Med | Volume | 24 |
| Issue | 7 | Pages | 4341-4349 |
| PubMed ID | 32119762 | Mgi Jnum | J:313310 |
| Mgi Id | MGI:6705390 | Doi | 10.1111/jcmm.15096 |
| Citation | Zhang W, et al. (2020) SARI prevents ocular angiogenesis and inflammation in mice. J Cell Mol Med 24(7):4341-4349 |
| abstractText | SARI (Suppressor of AP-1, regulated by IFN-beta) is known to play an important role in some systemic disease processes such an inflammatory conditions and cancer. We hypothesize that SARI may also play a role in ocular diseases involving inflammation and neovascularization. To explore our hypothesis, further, we investigated an endotoxin-induced uveitis (EIU) and experimental argon laser-induced choroidal neovascularization (CNV) model in SARI wild-type (SARI(WT) ) and SARI-deficient (SARI(-/-) ) mice. Through imaging, morphological and immunohistochemical (IHC) studies, we found that SARI deficiency exacerbated the growth of CNV. More VEGF-positive cells were presented in the retina of SARI(-/-) mice with CNV. Compared to SARI(WT) mice, more inflammatory cells infiltrated the ocular anterior segment and posterior segments in SARI(-/-) mice with EIU. Collectively, the results point to a potential dual functional role of SARI in inflammatory ocular diseases, suggesting that SARI could be a potential therapy target for ocular inflammation and neovascularization. |
