| First Author | Pofahl M | Year | 2021 |
| Journal | Elife | Volume | 10 |
| PubMed ID | 33709911 | Mgi Jnum | J:327579 |
| Mgi Id | MGI:6728234 | Doi | 10.7554/eLife.65786 |
| Citation | Pofahl M, et al. (2021) Synchronous activity patterns in the dentate gyrus during immobility. Elife 10:e65786 |
| abstractText | The hippocampal dentate gyrus is an important relay conveying sensory information from the entorhinal cortex to the hippocampus proper. During exploration, the dentate gyrus has been proposed to act as a pattern separator. However, the dentate gyrus also shows structured activity during immobility and sleep. The properties of these activity patterns at cellular resolution, and their role in hippocampal-dependent memory processes have remained unclear. Using dual-color in vivo two-photon Ca(2+) imaging, we show that in immobile mice dentate granule cells generate sparse, synchronized activity patterns associated with entorhinal cortex activation. These population events are structured and modified by changes in the environment; and they incorporate place- and speed cells. Importantly, they are more similar than expected by chance to population patterns evoked during self-motion. Using optogenetic inhibition, we show that granule cell activity is not only required during exploration, but also during immobility in order to form dentate gyrus-dependent spatial memories. |
