| First Author | Park SH | Year | 2024 |
| Journal | Life Sci Alliance | Volume | 7 |
| Issue | 12 | PubMed ID | 39266299 |
| Mgi Jnum | J:359164 | Mgi Id | MGI:7732214 |
| Doi | 10.26508/lsa.202302041 | Citation | Park SH, et al. (2024) Crosstalk between bone metastatic cancer cells and sensory nerves in bone metastatic progression. Life Sci Alliance 7(12) |
| abstractText | Although the role of peripheral nerves in cancer progression has been appreciated, little is known regarding cancer/sensory nerve crosstalk and its contribution to bone metastasis and associated pain. In this study, we revealed that the cancer/sensory nerve crosstalk plays a crucial role in bone metastatic progression. We found that (i) periosteal sensory nerves expressing calcitonin gene-related peptide (CGRP) are enriched in mice with bone metastasis; (ii) cancer patients with bone metastasis have elevated CGRP serum levels; (iii) bone metastatic patient tumor samples express elevated calcitonin receptor-like receptor (CRLR, a CGRP receptor component); (iv) higher CRLR levels in cancer patients are negatively correlated with recurrence-free survival; (v) CGRP induces cancer cell proliferation through the CRLR/p38/HSP27 pathway; and (vi) blocking sensory neuron-derived CGRP reduces cancer cell proliferation in vitro and bone metastatic progression in vivo. This suggests that CGRP-expressing sensory nerves are involved in bone metastatic progression and that the CGRP/CRLR axis may serve as a potential therapeutic target for bone metastasis. |
