|  Help  |  About  |  Contact Us

Publication : BMP9 and BMP10 are critical for postnatal retinal vascular remodeling.

First Author  Ricard N Year  2012
Journal  Blood Volume  119
Issue  25 Pages  6162-71
PubMed ID  22566602 Mgi Jnum  J:189049
Mgi Id  MGI:5444100 Doi  10.1182/blood-2012-01-407593
Citation  Ricard N, et al. (2012) BMP9 and BMP10 are critical for postnatal retinal vascular remodeling. Blood 119(25):6162-71
abstractText  ALK1 is a type I receptor of the TGF-beta family that is involved in angiogenesis. Circulating BMP9 was identified as a specific ligand for ALK1 inducing vascular quiescence. In this work, we found that blocking BMP9 with a neutralizing antibody in newborn mice significantly increased retinal vascular density. Surprisingly, Bmp9-KO mice did not show any defect in retinal vascularization. However, injection of the extracellular domain of ALK1 impaired retinal vascularization in Bmp9-KO mice, implicating another ligand for ALK1. Interestingly, we detected a high level of circulating BMP10 in WT and Bmp9-KO pups. Further, we found that injection of a neutralizing anti-BMP10 antibody to Bmp9-KO pups reduced retinal vascular expansion and increased vascular density, whereas injection of this antibody to WT pups did not affect the retinal vasculature. These data suggested that BMP9 and BMP10 are important in postnatal vascular remodeling of the retina and that BMP10 can substitute for BMP9. In vitro stimulation of endothelial cells by BMP9 and BMP10 increased the expression of genes involved in the Notch signaling pathway (Jagged1, Dll4, Hey1, Hey2, Hes1) and decreased apelin expression, suggesting a possible cross-talk between these pathways and the BMP pathway.
Quick Links:
 
Quick Links:
 

Expression

Publication --> Expression annotations

 

Other

4 Bio Entities

Trail: Publication

0 Expression