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Allele : b2b1941Clo Mutant line 1941; Bench to Bassinet Program (B2B/CVDC), mutation 1941 Cecilia Lo
Primary Identifier  MGI:5446162 Allele Type  Chemically induced (ENU)
Gene  b2b1941Clo Strain of Origin  C57BL/6J
Is Recombinase  false Is Wild Type  false
Project Collection  B2B/CvDC
description  Summative Diagnosis:
Cardiac phenotype: Persistent truncus arteriousus (PTA), pulmonary atresia (PA), transposition of the great arteries (d-TGA), atrioventricular septal defect (AVSD), major aortopulmonary collateral artery (MAPCA), aortic arch anomalies and vascular ring
Noncardiac phenotype: Cleft palate, micrognathia, micropthalmia, thymus aplasia, tracheoesophageal fistula, hydronephrosis, duplex kidney

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID Code Description
0541 Truncus arteriosus type 4a
0700 D-loop transposition of the great arteries
1000 Pulmonary atresia congenital
1100 Atrioventricular canal (endocardial cushion defect)
2760 Vascular ring
2771 Multiple major aortopulmonary collateral arteries (mapcas)
4202 Tracheoesophageal fistula
4502 Hydronephrosis
4609 Velocardiofacial syndrome
4610 DiGeorge syndrome
4876 Cleft palate
4877 Microphthalmia

molecularNote  This ENU-induced mutation was isolated in a screen at the University of Pittsburgh.
  • synonyms:
  • Unicorn,
  • Unicorn
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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