Primary Identifier | MGI:5446790 | Allele Type | Targeted |
Attribute String | Recombinase | Gene | Tcf21 |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | true | Is Wild Type | false |
molecularNote | by homologous recombination in ES cells, exon 1 of the Tcf21 gene was replaced with a cassette encoding a nuclear localized cre recombinase, neomycin selection cassette and beta-actin polyadenylation sequence. One ES cell line produced chimeras that gave germline transmission of the allele. |