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Allele : Erbb3<tm1.1(ERBB3)Mul> erb-b2 receptor tyrosine kinase 3; targeted mutation 1.1, William J Muller

Primary Identifier  MGI:5446930 Allele Type  Targeted
Gene  Erbb3 Transmission  Germline
Strain of Origin  129P2/OlaHsd Is Recombinase  false
Is Wild Type  false
molecularNote  Most of exon 12 through exon 16 was replaced by a construct containing a human cDNA with point mutations (A to T at the second codon position) that replace tyrosines with alanines at positions 941, 1054, 1197, 1222, 1260, 1276 and 1289 (within YXXM of the PI3K p85 concensus binding sites) and a floxed neo cassette. Cre-mediated recombination removed the neo cassette.
  • mutations:
  • Insertion,
  • Intragenic deletion
  • synonyms:
  • ErbB3<delta85>,
  • ErbB3<delta85>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

4 Publication categories

Trail: Allele