| First Author | Zhou Z | Year | 2023 |
| Journal | Cell Rep | Volume | 42 |
| Issue | 5 | Pages | 112424 |
| PubMed ID | 37086405 | Mgi Jnum | J:351838 |
| Mgi Id | MGI:7491475 | Doi | 10.1016/j.celrep.2023.112424 |
| Citation | Zhou Z, et al. (2023) CX3CR1(hi) macrophages sustain metabolic adaptation by relieving adipose-derived stem cell senescence in visceral adipose tissue. Cell Rep 42(5):112424 |
| abstractText | Adipose-derived stem cells (ASCs) drive healthy visceral adipose tissue (VAT) expansion via adipocyte hyperplasia. Obesity induces ASC senescence that causes VAT dysfunction and metabolic disorders. It is challenging to restrain this process by biological intervention, as mechanisms of controlling VAT ASC senescence remain unclear. We demonstrate that a population of CX3CR1(hi) macrophages is maintained in mouse VAT during short-term energy surplus, which sustains ASCs by restraining their senescence, driving adaptive VAT expansion and metabolic health. Long-term overnutrition induces diminishment of CX3CR1(hi) macrophages in mouse VAT accompanied by ASC senescence and exhaustion, while transferring CX3CR1(hi) macrophages restores ASC reservoir and triggers VAT beiging to alleviate the metabolic maladaptation. Mechanistically, visceral ASCs attract macrophages via MCP-1 and shape their CX3CR1(hi) phenotype via exosomes; these macrophages relieve ASC senescence by promoting the arginase1-eIF5A hypusination axis. These findings identify VAT CX3CR1(hi) macrophages as ASC supporters and unravel their therapeutic potential for metabolic maladaptation to obesity. |
