Primary Identifier | MGI:5446657 | Allele Type | Transgenic |
Attribute String | Inserted expressed sequence | Gene | Tg(Vav1-Lin28b)C3Apla |
Strain of Origin | C57BL/6 | Is Recombinase | false |
Is Wild Type | false |
description | Phenotypic Similarity to Human Syndrome: peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) (J:189197). |
molecularNote | The murine Lin28b cDNA was inserted into the HS 21/45-vav vector containing 3' and 5' Vav1-regulatory elements. The Vav1-regulatory elements target expression of Lin28b to hematopoietic tissues. Transgenic mRNA is expressed in the bone marrow, spleen and thymus. Three lines were made, C3, D4, and D10. |