| Primary Identifier | MGI:5462093 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Notch3 |
| Transmission | Germline | Strain of Origin | 129S/SvEv |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 4 was replaced with one in which a C to T transition resulted in the amino acid substitution of cysteine for arginine at position 170 (R170C), mimicking a mutation associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) in humans. A silent mutation creating a HincII site was introduced in exon 4 for genotyping purposes. Cre-mediated recombination removed the floxed neo cassette inserted downstream of exon 5. |
