Primary Identifier | MGI:5464997 | Allele Type | Spontaneous |
Gene | Foxn1 | Inheritance Mode | Recessive |
Strain of Origin | B6.SJL-Ptprc<a> Pepc<b>/BoyJ | Is Recombinase | false |
Is Wild Type | false |
molecularNote | This spontaneous mutation, which fails to complement the original nude mutation, has a 7 nucleotide deletion encompassing chromosome 11 nucleotides 78,371,200-206 (GRCm38). This causes a frameshift that leads to the introduction of 186 novel amino acids beginning at residue 114 and then an early termination codon within the forkhead DNA binding domain. |