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Allele : Lrrk2<tm2.1Mjff> leucine-rich repeat kinase 2; targeted mutation 2.1, The Michael J Fox Foundation
Primary Identifier  MGI:5466852 Allele Type  Targeted
Attribute String  Humanized sequence Gene  Lrrk2
Transmission  Germline Strain of Origin  C57BL/6N
Is Recombinase  false Is Wild Type  false
molecularNote  A targeting vector was designed to introduce a threonine to asparagine (T1348N) substitution at codon 1348 in exon 29 of the endogeneous locus. In addition, an FRT-flanked neomycin resistance (neo) cassette was introduced approximately 200 bp downstream of exon 29. Flp-mediated recombination removed the FRT-flanked neo cassette.
  • mutations:
  • Insertion,
  • Nucleotide substitutions
  • synonyms:
  • Lrrk2<T1348N>,
  • Lrrk2<T1348N>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele

0 Driven By

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Trail: Allele




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