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Allele : Atm<tm1.1Shzh> ataxia telangiectasia mutated; targeted mutation 1.1, Shan Zha

Primary Identifier  MGI:5463773 Allele Type  Targeted
Gene  Atm Transmission  Germline
Strain of Origin  129S6/SvEvTac Is Recombinase  false
Is Wild Type  false
molecularNote  Exon 3 was replaced with a floxed neo cassette and a modified exon 3 in which an A to C and T to A transversion results in the amino acid substitutions of alanine for aspartic acid at position 2880 (D2880A) and lysine for asparagine at position 2885 (N2885K). These mutations result in a kinase dead protein. Cre-mediated recombination removed the neo cassette.
  • mutations:
  • Insertion,
  • Nucleotide substitutions
  • synonyms:
  • Atm<KD>,
  • Atm<KD>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

6 Publication categories

Trail: Allele