| First Author | Yu Q | Year | 2023 |
| Journal | iScience | Volume | 26 |
| Issue | 12 | Pages | 108518 |
| PubMed ID | 38089576 | Mgi Jnum | J:343203 |
| Mgi Id | MGI:7564497 | Doi | 10.1016/j.isci.2023.108518 |
| Citation | Yu Q, et al. (2023) C1q is essential for myelination in the central nervous system (CNS). iScience |
| abstractText | Myelin sheath in the central nervous system (CNS) is essential for efï¬cient action potential conduction. Microglia, the macrophages in the CNS, are suggested to regulate myelin development. However, the speciï¬c involvement of microglia in initial myelination is yet to be elucidated. Here, ï¬rst, by culturing neu-ral stem cells, we demonstrated that myelin sheath formation only occurred in the presence of a microglia-conditioned medium. Furthermore, the absence of C1q, a microglia-derived factor, resulted in myelination failure in the neural stem cell culture. Additionally, adding native human C1q protein was sufï¬cient to induce myelination in vitro. Finally, in the C1q conditional knockout mouse model (C1qaFL/FL: Cx3cr1CreER), C1q deï¬ciency prior to the onset of myelination led to reduced myelin thickness and elevated g-ratio during initial myelination. This study uncovers the pivotal role of microglia-derived C1q in developmental myelination and could potentially pave the way for new therapeutic strategies for treat-ing demyelinating diseases. |
