| First Author | Wang J | Year | 2013 |
| Journal | Nat Immunol | Volume | 14 |
| Issue | 1 | Pages | 34-40 |
| PubMed ID | 23142774 | Mgi Jnum | J:191085 |
| Mgi Id | MGI:5460935 | Doi | 10.1038/ni.2456 |
| Citation | Wang J, et al. (2013) Neutrophil infiltration during inflammation is regulated by PILRalpha via modulation of integrin activation. Nat Immunol 14(1):34-40 |
| abstractText | Acute inflammatory responses are important in host defense, whereas dysregulated inflammation results in life-threatening complications. Here we found that paired immunoglobulin-like type 2 receptor alpha (PILRalpha), an inhibitory receptor containing immunoreceptor tyrosine-based inhibitory motifs (ITIMs), negatively regulated neutrophil infiltration during inflammation. Pilra(-/-) mice had increased neutrophil recruitment to inflammatory sites and were highly susceptible to endotoxin shock. Pilra(-/-) neutrophils showed enhanced transmigration ability and increased adhesion to the beta(2) integrin ligand ICAM-1. PILRalpha expressed on neutrophils constitutively associated in cis with its ligands, resulting in clustering of PILRalpha during stimulation with a chemoattractant. Clustering of PILRalpha enhanced ITIM-mediated signaling, thus modulating beta(2) integrin inside-out activation. These data demonstrate that neutrophil recruitment in inflammatory responses is regulated by PILRalpha via modulation of integrin activation. |
