| Primary Identifier | MGI:5476630 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Eno2-MFN2)L916Ugfm |
| Strain of Origin | (C57BL/6 x DBA/2)F1 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | This transgene contains the rat neuron-specific enolase 2 gene promoter driving expression of the the wild-type human mitofusin 2 gene, which is followed by the SV40 polyadenylation signal. Expression of human MFN2 mRNA was demonstrated by reverse transcription-polymerase chain reaction (RT-PCR) analysis in spinal cord, dorsal root ganglion, whole brain, cortex, brainstem and cerebellum, but not in pancreas, of transgenic mice; trangene expression increases the total Mfn2/MFN2 transcript level in spinal cord to 2.3-fold that of the endogenous mouse transcript, as determined by semi-quantitative RT-PCR. |
