| First Author | Nagasu H | Year | 2011 |
| Journal | Biochem Biophys Res Commun | Volume | 407 |
| Issue | 1 | Pages | 39-43 |
| PubMed ID | 21354104 | Mgi Jnum | J:171953 |
| Mgi Id | MGI:5002435 | Doi | 10.1016/j.bbrc.2011.02.089 |
| Citation | Nagasu H, et al. (2011) Overexpression of klotho protein modulates uninephrectomy-induced compensatory renal hypertrophy by suppressing IGF-I signals. Biochem Biophys Res Commun 407(1):39-43 |
| abstractText | The klotho gene is highly expressed in the distal convoluted tubule of the kidney, while its encoded protein has many physiological and pathophysiological renal roles. We investigated the effect of klotho protein on physiological compensatory renal hypertrophy after nephrectomy in klotho transgenic (KLTG) mice. Renal hypertrophy was suppressed in KLTG mice compared with wild-type mice, and this was associated with suppression of insulin growth factor-1 (IGF-1) signaling by klotho protein. In vitro, IGF-1 signaling was suppressed in human proximal tubular cells transfected with the klotho plasmid. Our data suggest that klotho modulates compensatory renal hypertrophy after nephrectomy via suppression of the IGF-1 signaling pathway, indicating a novel physiological role for klotho protein in the kidney. |
