| Primary Identifier | MGI:5486676 | Allele Type | Targeted |
| Attribute String | Conditional ready, No functional change | Gene | Gjb6 |
| Transmission | Germline | Strain of Origin | 129 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A loxP site was inserted upstream of exon 3 and a floxed pgk-hygromycin cassette was inserted downstream of exon 3 via homologous recombination. Quantitative PCR and immunoblot analysis indicate a decrease in mRNA and protein expression in the inner ear of homozygous mice. Expression of Gjb2 mRNA and protein are also reduced in the inner ear of homozygous mice. |
