| Primary Identifier | MGI:5488954 | Allele Type | Spontaneous |
| Attribute String | Null/knockout | Gene | Kif14 |
| Inheritance Mode | Recessive | Strain of Origin | DBA/2NJcl |
| Is Recombinase | false | Is Wild Type | false |
| description | laggard The laggard phenotype was first observed in F2 progeny of a chimeric mouse derived from 129X1/SvJ RW-4 ES cells, targeted at another locus, and a (C57BL/6NJcl x DBA/2NJcl)F1 female. During the mapping of lag, it was found to have occurred in a DBA/2NJcl-derived genomic region. (J:195809) |
| molecularNote | A spontaneous G-to-A point mutation in intron 4 disrupts the 3' splice acceptor site for exon 5 by changing it from CAG to CAA. Western blot analysis confirmed the expression of three aberrant proteins and the absence of the wild-type protein in the brain. |
