| First Author | Schwarz F | Year | 2015 |
| Journal | Elife | Volume | 4 |
| PubMed ID | 25846707 | Mgi Jnum | J:220809 |
| Mgi Id | MGI:5636517 | Doi | 10.7554/eLife.06184 |
| Citation | Schwarz F, et al. (2015) Siglec receptors impact mammalian lifespan by modulating oxidative stress. Elife 4 |
| abstractText | Aging is a multifactorial process that includes the lifelong accumulation of molecular damage, leading to age-related frailty, disability and disease, and eventually death. In this study, we report evidence of a significant correlation between the number of genes encoding the immunomodulatory CD33-related sialic acid-binding immunoglobulin-like receptors (CD33rSiglecs) and maximum lifespan in mammals. In keeping with this, we show that mice lacking Siglec-E, the main member of the CD33rSiglec family, exhibit reduced survival. Removal of Siglec-E causes the development of exaggerated signs of aging at the molecular, structural, and cognitive level. We found that accelerated aging was related both to an unbalanced ROS metabolism, and to a secondary impairment in detoxification of reactive molecules, ultimately leading to increased damage to cellular DNA, proteins, and lipids. Taken together, our data suggest that CD33rSiglecs co-evolved in mammals to achieve a better management of oxidative stress during inflammation, which in turn reduces molecular damage and extends lifespan. |
