| Primary Identifier | MGI:5491039 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence, Reporter | Gene | Tg(MECP2*G273X/GFP)AHzo |
| Strain of Origin | FVB | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | A human PAC (PAC671D9) containing only the MECP2 locus and regulatory elements was modified to replace amino acids 270-486 with MECP2 sequence encoding amino acids 270-272, a 6 amino acid poly-serine linker and a C-terminal GFP tag. Two lines were generated. Expression of the transgene faithfully reproduces the distribution, abundance, and subnuclear localization of MECP2 in the brain. |
