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Allele : Tg(Pten)GPpp transgene insertion G, Pier Paolo Pandolfi
Primary Identifier  MGI:5491064 Allele Type  Transgenic
Attribute String  Inserted expressed sequence Gene  Tg(Pten)GPpp
Strain of Origin  (C57BL/6 x CBA)F2 Is Recombinase  false
Is Wild Type  false
molecularNote  The transgene comprises the 218.50-kb mouse genomic DNA insert of the bacterial artificial chromosome (BAC) clone RP23-215F15 (RPCI library; C57BL/6J), which contains the entire phosphatase and tensin homolog (Pten) gene. Immunoblot analysis of whole-cell protein extracts from mouse embryonic fibroblasts (MEFs) cultured from E13.5 embryos of this line shows that they express the protein at 3.5-fold the level of wild-type MEFs; elevated levels are observed in both cytoplasmic and nuclear MEF extracts. Elevated PTEN protein expression is observed in embryos and in all adult tissues analyzed: brain, lung, kidney, heart, thymus, liver, spleen, and white and brown adipose tissue.
  • mutations:
  • Insertion
  • synonyms:
  • Tg(RP23-215F15)GPpp,
  • Super-PTEN line 3,
  • Super-PTEN line 3,
  • BAC-PTEN TG,
  • Super-PTEN,
  • BAC-PTEN TG line 3,
  • BAC-PTEN TG line 3,
  • BAC-PTEN TG,
  • Tg(RP23-215F15)GPpp,
  • Super-PTEN
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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