Primary Identifier | MGI:5491825 | Allele Type | Targeted |
Gene | L1cam | Transmission | Germline |
Strain of Origin | 129S4/SvJae-Tg(Prm-cre)70Og | Is Recombinase | false |
Is Wild Type | false |
molecularNote | This allele encodes a modified protein truncated at amino acid 1180. This allele preserves binding to AP-2 and ERM proteins but not binding to Ank2 or RanBPM. Cre-mediated recombination removed the floxed neo cassette inserted into intron 26. Western blot analysis confirmed expression of the truncated protein in the brain. |