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Allele : Tg(Sox2-cre/Esr1*)20Jheb transgene insertion 20, Jean M Hebert
Primary Identifier  MGI:5494289 Allele Type  Transgenic
Attribute String  Inducible, Recombinase Gene  Tg(Sox2-cre/Esr1*)20Jheb
Strain of Origin  FVB Induced With  tamoxifen
Is Recombinase  true Is Wild Type  false
molecularNote  The coding sequence of the Sox2 gene in a BAC (RP23-2B8) was replaced with the coding sequence for a tamoxifen-inducible cre/estrogen receptor fusion (cre/Esr1*; CreERTM). The construct was injected into pronuclei of fertilized FVB oocytes. 3 transgene-positive founders were obtained (20, 34, and 36). Founders were bred to reporter mice, administered tamoxifen at E9.5, and embryos were analyzed for recombination activity at E10.5. Line 20 progeny displayed the strongest lacZ expression. This line was characterized further.
  • mutations:
  • Insertion
  • synonyms:
  • Sox2-CreER,
  • Sox2-CreER,
  • Sox2-CreER<TM>,
  • Sox2-CreER<TM>
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0 Mutation Involves

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Mouse alleles --> Mammalian phenotypes (MP terms)

 

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