Primary Identifier | MGI:5508226 | Allele Type | Targeted |
Gene | Gnao1 | Transmission | Germline |
Strain of Origin | 129S1/Sv-Oca2<+> Tyr<+> Kitl<+> | Is Recombinase | false |
Is Wild Type | false |
molecularNote | Exon 5 was replaced with a modified exon 5 that contains nculeotide substitutions (GGC to AGT) that result in the amino acid substitution of serine for glycine at position 184 (G184S). This mutation blocks RGS binding. A floxed neo cassette was inserted between the modified exon 5 and exon 6. |