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Allele : Gnao1<tm2Rneu> guanine nucleotide binding protein, alpha O; targeted mutation 1, Richard R Neubig

Primary Identifier  MGI:5508226 Allele Type  Targeted
Gene  Gnao1 Transmission  Germline
Strain of Origin  129S1/Sv-Oca2<+> Tyr<+> Kitl<+> Is Recombinase  false
Is Wild Type  false
molecularNote  Exon 5 was replaced with a modified exon 5 that contains nculeotide substitutions (GGC to AGT) that result in the amino acid substitution of serine for glycine at position 184 (G184S). This mutation blocks RGS binding. A floxed neo cassette was inserted between the modified exon 5 and exon 6.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • Galphao<G184S>,
  • Galphao<G184S>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

9 Publication categories

Trail: Allele