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Allele : Psap<tm4.1Ggb> prosaposin; targeted mutation 4.1, Gregory A Grabowski
Primary Identifier  MGI:5510529 Allele Type  Targeted
Gene  Psap Transmission  Germline
Strain of Origin  129S/SvEv Is Recombinase  false
Is Wild Type  false
molecularNote  Nucleotide substitutions result in the amino acid substitution of Cys 4 of saposins A and B located in exon 4 (saposin A domain) and exon 7 (saposin B domain) with phenylalanine. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted upstream of the modified exon 7. Western blot analysis confirmed the absence of saponin A and B, overexpression of saponin C and normal expression of saponin D in the cerebrum and liver.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • AB<->,
  • AB<->
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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