| Primary Identifier | MGI:5510713 | Allele Type | Chemically induced (ENU) |
| Attribute String | Not Specified | Gene | Crkl |
| Strain of Origin | C57BL/6JAnu | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The molecular lesion is a T-to-C substitution in the Crkl gene, at position Chr16:17,452,790 (GRCm38). This nucleotide substitution resides 2 nucleotides downstream of exon 1. The mutant transcript is predicted to result in a loss of a putative splice donor and/or generation of additional exonic splice enhancers. Mutant embryos exhibit a loss of transcript expression compared to controls. Western blot analysis of protein extracted from whole E13.5 embryos confirmed the loss of protein in mutant mice. |
