| Primary Identifier | MGI:5518935 | Allele Type | Targeted |
| Attribute String | Conditional ready, Null/knockout | Gene | Trp53 |
| Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 5 was replaced with a modified one in which nucleotide substitutions (GA-to-CG) result in the amino acid substitution of glutamic acid with arginine at position 177 (p.E177R), mimicking a mutation found in some human tumors. A loxP site flanked puromycin resistance gene cassette was inserted into intron 1. Authors state that this is a null allele. |
