| Primary Identifier | MGI:5523235 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(Pcp2-ATXN3*69Q)bHirai |
| Strain of Origin | C57BL/6NCrSlc | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The cDNA encoding a N-terminal-truncated form (lacking 286 amino-acid residues) of human ATAXIN-3 with 69 glutamine repeats is driven by a Purkinje-cell specific L7 promoter (Pcp2). The ATG start codon in exon 2 of Pcp2 was mutated to inhibit the expression of exons 1-3. In addition an N-terminal hemagglutinin epitope was added. Three lines were generated, a, b, and c. |
