| First Author | Zemla R | Year | 2022 |
| Journal | Cell Rep | Volume | 41 |
| Issue | 8 | Pages | 111700 |
| PubMed ID | 36417882 | Mgi Jnum | J:354708 |
| Mgi Id | MGI:7407993 | Doi | 10.1016/j.celrep.2022.111700 |
| Citation | Zemla R, et al. (2022) Task-selective place cells show behaviorally driven dynamics during learning and stability during memory recall. Cell Rep 41(8):111700 |
| abstractText | Decades of work propose that hippocampal activity supports internal representation of learned experiences and contexts, allowing individuals to form long-term memories and quickly adapt behavior to changing environments. However, recent studies insinuate hippocampal representations can drift over time, raising the question: how could the hippocampus hold stable memories when activity of its neuronal maps fluctuates? We hypothesized that task-dependent hippocampal maps set by learning rules and structured attention stabilize as a function of behavioral performance. To test this, we imaged hippocampal CA1 pyramidal neurons during learning and memory recall phases of a new task where mice use odor cues to navigate between two reward zones. Across learning, both orthogonal and overlapping task-dependent place maps form rapidly, discriminating trial context with strong correlation to behavioral performance. Once formed, task-selective place maps show increased long-term stability during memory recall phases. We conclude that memory demand and attention stabilize hippocampal activity to maintain contextually rich spatial representations. |
