Primary Identifier | MGI:5523990 | Allele Type | Targeted |
Gene | Trp53 | Transmission | Germline |
Strain of Origin | 129S6/SvEvTac | Is Recombinase | false |
Is Wild Type | false |
molecularNote | Mice carrying a conditional Trp53 allele lacking the AS (Alternative Splicing) exon were crossed to Tg(Pgk1-cre)1Lni mice to excise the stop cassette. The resultant allele produces mRNA from which only Trp53 proteins with the 'classical' C terminal domain can be synthesized. |