| Primary Identifier | MGI:5529365 | Allele Type | Targeted |
| Attribute String | Humanized sequence, Null/knockout, Reporter | Gene | Mecp2 |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Nucleotide substitution(s) in exon 4 resulted in the amino acid substitution of cysteine for arginine at position 306 (R306C). This mutation abolishes the interaction with NCoR/SMRT components. An EGFP was fused in-frame downstream of the coding sequence in exon 4. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted downstream of EGFP. The R306C mutation represents 9% of Rhett Syndrome missense mutations. |
