| Primary Identifier | MGI:5543408 | Allele Type | Targeted |
| Attribute String | Not Specified | Gene | Grm5 |
| Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Two point mutations (A>G and T>G) were introduced in exon 8. A loxP site flanked neomycin resistance gene cassette was inserted into intron 7. The neo cassette was removed through subsequent cre-mediated recombination. The two mutations change a threonine and serine codon to alanine (p.Thr1123Ala and p.Ser1126Ala). This prevents phosphorylization of those two residues in the encoded protein. |
