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Allele : Topbp1<tm1.1Zqw> topoisomerase (DNA) II binding protein 1; targeted mutation 1.1, Zhao-Qi Wang
Primary Identifier  MGI:5544423 Allele Type  Targeted
Gene  Topbp1 Transmission  Germline
Strain of Origin  129P2/OlaHsd Is Recombinase  false
Is Wild Type  false
molecularNote  Tryptophan 1147 in exon 20, the core indispensable aromatic residue in the ATR activating domain was changed to arginine by introducing a T3439C mutation. In addition an FRT flanked neo cassette was inserted in intron 19. Flp mediated recombination removed the neo cassette leaving a single FRT site in intron 19. Immunoblot analysis confirmed similar levels of protein expressing in heterozygous and wild-type MEFs.
  • mutations:
  • Insertion,
  • Single point mutation
  • synonyms:
  • TopBP1<W1147R>,
  • TopBP1<W1147R>,
  • TopBP1<ki>,
  • TopBP1<ki>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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0 Driven By

4 Publication categories

Trail: Allele




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