| First Author | Guillamot M | Year | 2011 |
| Journal | Sci Rep | Volume | 1 |
| Pages | 189 | PubMed ID | 22355704 |
| Mgi Jnum | J:206116 | Mgi Id | MGI:5547904 |
| Doi | 10.1038/srep00189 | Citation | Guillamot M, et al. (2011) Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription. Sci Rep 1:189 |
| abstractText | Cdc14 is an essential phosphatase in yeast but its role in the mammalian cell cycle remains obscure. We report here that Cdc14b-knockout cells display unscheduled induction of multiple cell cycle regulators resulting in early entry into DNA replication and mitosis from quiescence. Cdc14b dephosphorylates Ser5 at the C-terminal domain (CTD) of RNA polymerase II, a major substrate of cyclin-dependent kinases. Lack of Cdc14b results in increased CTD-Ser5 phosphorylation, epigenetic modifications that mark active chromatin, and transcriptional induction of cell cycle regulators. These data suggest a function for mammalian Cdc14 phosphatases in the control of transcription during the cell cycle. |
